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217509 LDN-211904 (N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide Ooxalate, EphB3 Inhibitor) CAS:

Specifications
Grade
Highly Purified
Molecular Formula
C₂₁H₂₁ClN₄O₅
Molecular Weight
444.9
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10uM in cells. When profiled against a panel of 288 kinases at 5uM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38b, and Qik.

Molecular Formula
C₂₁H₂₁ClN₄O₅
Molecular Weight
444.9
Soluility
DMSO (50mg/ml, clear, nearly colorless solution)
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
≥99% (HPLC)
Form
Supplied as an off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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