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217669 PK11195 CAS: 85532-75-8

Specifications
CAS Number
85532-75-8
Grade
Highly Purified
MDL Number
MFCD00069334
Molecular Formula
C₂₁H₂₁ClN₂O
Molecular Weight
352.86
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100uM).

CAS Number
85532-75-8
Synonyms
TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
Molecular Formula
C₂₁H₂₁ClN₂O
Solubility
DMSO
Primary Target
peripheral bezodiazepine receptor
Primary Target Ki
20nM
Molecular Weight
352.86
Appearance
Supplied as a white solid.
Purity
≥98% (HPLC)
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~98% (HPLC)
Concentration
Not determined
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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