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217873 VU0155041, Sodium Salt (cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Sodium Salt) CAS:

Specifications
Grade
Highly Purified
Molecular Formula
C14H14Cl2NNaO3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

A highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7uM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventricularlly (icv).

Formula
C14H14Cl2NNaO3
Solubility
H2O
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~99% (HPLC)
Concentration
Not determined
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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