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254470 A 438079 hydrochloride CAS: 899431-18-6

Specifications
References
CAS Number
899431-18-6
Grade
Purified
Molecular Formula
C₁₃H₁₀Cl₃N₅
Molecular Weight
342.61
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; A 438079

Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.

Alternate Name
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; A 438079
CAS Number
899431-18-6
Molecular Formula
C₁₃H₁₀Cl₃N₅
Molecular Weight
342.61
Purity
≥98% (HPLC)
References
Nelson et al (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J.Med.Chem. 49 3659 PMID: 16759108|Donnelly-Roberts and Jarvis (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 151 571 PMID: 17471177|McGaraughty et al (2007) P2X7-related modulation of pathological nociception in rats. Neuroscience 146 1817 PMID: 17478048|Fernandes et al (2016) Methamphetamine alters microglial immune function through P2X7R signaling. J.Neuroinflammation. 13 91 PMID: 7117066
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