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254668 ARL 67156 Trisodium Salt CAS: 1021868-83-6

Specifications
References
CAS Number
1021868-83-6
Grade
Highly Purified
Molecular Formula
C₁₅H₂₁Br₂N₅Na₃O₁₂P₃
Molecular Weight
785.05
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
0°C
N,N-diethyl-5'-Adenylic Acid 5'-anhydride with P,P'-(Dibromomethylene)bis[phosphonic Acid]Sodium Salt

Inhibitor of ecto-ATPase which blocks the hydrolysis of nucleoside diphosphates and triphosphates in extracellular space. The compound inhibits NTPDase1, NTPDase 3, NTPDase 8 and NPP1and prolongs the effect of ATP on purinergic P2 receptors in environment with physiological concentrations of nucleotides. The compound has variable effectiveness as ecto-ATP inhibitor in mouse, rat, human and guineia pig tissues.

Synonyms
N,N-diethyl-5'-Adenylic Acid 5'-anhydride with P,P'-(Dibromomethylene)bis[phosphonic Acid]Sodium Salt
CAS No
1021868-83-6 Free Acid: 160928-38-1
Molecular Formula
C₁₅H₂₁Br₂N₅Na₃O₁₂P₃
Molecular Weight
785.05
Appearance
White to off-white powder
Purity
≥99% (HPLC)
Identity (1H NMR)
Conforms to reference
Elemental analysis (C)/(H)/(N) (on dry basis)
C;22.55 - 23.35% H:2.30 - 3.10% N:8.52 - 9.32%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Lévesque et al (2007). Specificity of the ecto‐ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases. British Journal of Pharmacology 152(1):141-150
USBio References
No references available
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