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254676 AS 19 CAS: 1000578-26-6

Specifications
References
CAS Number
1000578-26-6
Grade
Highly Purified
Molecular Formula
C₁₈H₂₅N₃
Molecular Weight
283.41
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin

Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced

Synonyms
(2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
CAS Number
1000578-26-6
Molecular Formula
C₁₈H₂₅N₃
Molecular Weight
283.41
Appearance
Yellow, lyophilized oil and may be very hard to visualize. Solutions should be made by adding solvent directly to the vial. The vial should then be vortexed vigorously to ensure the product has completely dissolved.
Purity
≥98% (HPLC)
Solubility
DMSO, EtOH, DMF
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Brenchat, A., Romero, L., García, M., et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain 141(3), 239-247 (2009).|2. Perez-García, G.S. and Meneses, A. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav. Brain Res. 163(1), 136-140 (2005).|3. Li, S.-F., Zhang, Y.-Y., Li, Y.-Y., et al. Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic pain. Pharmacol. Biochem. Behav. 127, 49-55 (2014).
USBio References
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