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255036 CP 339818 hydrochloride CAS: 478341-55-8

Specifications
References
CAS Number
478341-55-8
Grade
Highly Purified
MDL Number
MFCD09878238
Molecular Formula
C₂₁H₂₄N₂•HCl
Molecular Weight
304.43
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

Synonyms
N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
CAS No
478341-55-8 Free Base: 185855-91-8
Molecular Formula
C₂₁H₂₄N₂•HCl
Molecular Weight
304.43
Appearance
White to off-white powder
Purity
≥98% (HPLC)
Solubility
DMSO (10mg/ml)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Lee, Y., et al.: Eur. J. Pharmacol., 581, 97 (2008)
USBio References
No references available
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