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255048 CRANAD 2 CAS: 1193447-34-5

Specifications
References
CAS Number
1193447-34-5
Grade
Purified
Molecular Formula
C23H25BF2N2O2
Molecular Weight
410.26
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron

Near-infrared probe that binds to Aβ40 aggregates (Kd = 38nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.

Synonyms
(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
CAS No
1193447-34-5
Molecular Formula
C23H25BF2N2O2
Molecular Weight
410.26
Appearance
Crystalline solid
Purity
≥98% (HPLC)
Solubility
DMSO [warming]
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Ran et al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257 PMID: 19807070|Ran et al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362 PMID: 21559413
USBio References
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