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257110 Wnt-C59 CAS: 1243243-89-1

Specifications
CAS Number
1243243-89-1
Grade
Highly Purified
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable.

CAS Number
1243243-89-1
Formula
C25H21N3O
Solubility
20mM in DMSO and to 20mM in ethanol
1H NMR
Consistent with structure
Mass Spectrum
Consistent with structure
Purity
≥99%
Storage
Store at -20°C
Pricing
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