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257145 YM 022 CAS: 145084-28-2

Specifications
References
CAS Number
145084-28-2
Grade
Highly Purified
MDL Number
MFCD00917023
Molecular Formula
C32H28N4O3
Molecular Weight
516.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
(R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea

YM 022, is a potent, selective non-peptide antagonist of the gastrin/cholecystokinin (CCK)-B receptor. (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively).

Synonyms
(R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea
CAS No
145084-28-2
Molecular Formula
C32H28N4O3
Molecular Weight
516.6
Purity (Chiral, HPLC)
≥99%
Appearance
White to off-white powder
Solubility
DMSO: 100mM; Ethanol: 10mM
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones. Beinborn et al., Yale J.Biol.Med., 1998;71:337. 2. Long-lasting cholecystokinin2 receptor blockade after a single subcutaneous injection of YF476 or YM022. Kitano et al,. Br.J.Pharmacol., 2000;130:699, 3. Pharmacological profile of YM022, a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro, Nishida et al., J.Pharmacol.Exp.Ther., 1994;269:725.
USBio References
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