An inhibitor of trehalase. Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9nM; IC50 = 0.7uM).1 It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi.2 This compound has also been used to study trehalase activity and trehalose biosynthesis.3
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