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299926 Anisodamine CAS: 55869-99-3

Specifications
References
CAS Number
55869-99-3
Grade
Plant Grade
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

Anisodamine, an anticholinergic drug, has antishock effect, which is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway. Anisodamine demonstrates a direct cardiac depressive action at the myocyte level, which may be related to, at least in part, NO production and cholinoceptor antagonism, it causes the changes of structure and function in the transmembrane domain of the Ca(2+)-ATPase from sarcoplasmic reticulum. Anisodamine, a vasoactive drug, can abate endogenous endotoxaemia subsequent to splanchnic vasoconstriction due to hypovolaemia, it alleviates inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1, and shows significant protective effects in an animal model of infusion phlebitis. Anisodamine also inhibits shiga toxin type 2-mediated tumor necrosis factor-alpha production in vitro and in vivo.

CAS Number
55869-99-3
Molecular Formula
C17H23NO4
Molecular Weight
305.374
Identification Method
Mass, NMR
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
≥ 98%
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Burns. 1997 Mar; 23(2):142-6.
USBio References
No references available
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