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366867 9-cis-Retinoic Acid CAS: 5300-03-8

Specifications
References
CAS Number
5300-03-8
Grade
Highly Purified
MDL Number
MFCD00270072
Molecular Formula
C9H14N4O5
Molecular Weight
258.2
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid; Alitretinoin, 9-cis-Tretinoin, Panretin

9-cis-Retinoic acid is a potent activator of all isoforms of retinoic acid receptor and the retinoid X receptor, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells.. It is reported to promote oligodendrocyte precursor cell differentiation and myelination and to also inhibit the synthesis of fatty acids and sterols in hepatocytes.

Synonyms
Alitretinoin, 9-cis-Tretinoin, Panretin
Chemical Name
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Molecular Formula
C9H14 N4O5
Molecular Weight
258.2
CAS Number
5300-03-8
Purity
≥98%
Applications
FA
Appearance
Crystalline solid
Storage
Product should be kept at -20°C. Soluble in organic solvents such as ethanol or DMSO.
Purity
~98%
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68(2), 397-406. 2. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. 3. MacDonald, P. N., Dowd, D. R., Nakajima, S., Galligan, M. A., Reeder, M. C., Haussler, C. A., Haussler, M. R. (1993). Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1, 25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Molecular and cellular biology, 13(9), 5907-5917.
USBio References
No references available
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