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366875 CNQX (6-Cyano-2,3-dihydroxy-7-nitroquinoxaline, FG-9065) CAS: 115066-14-3

Specifications
References
CAS Number
115066-14-3
Grade
Highly Purified
MDL Number
MFCD00069232
Molecular Formula
C9H4N4O4
Molecular Weight
232.2
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Synonyms
6-Cyano-2,3-dihydroxy-7-nitroquinoxaline, FG-9065
Chemical Name
7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
Molecular Formula
C9H4N4O4
Molecular Weight
232.2
CAS Number
115066-14-3
Purity
≥98%
Applications: FA
Appearance
Crystalline solid
Description
CNQX is a potent AMPA/kainate receptor antagonist. It also acts an antagonist to the NMDA receptor complex at the glycine site. It is reported to block the excitatory action of kainate and quisqualate on spinal neurons with little or no effect on that of NMDA.
Storage
Soluble in organic solvents such as DMSO. DMSO up to 100mM. Product should be kept at -20°C.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Blake, J. F., Brown, M. W., Collingridge, G. L. (1988). CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices.Neuroscience letters, 89(2), 182-186. 2. Honor, T., Drejer, J., Nielsen, E. & Oslash, Nielsen, M. (1989). Non-NMDA glutamate receptor antagonist 3 H-CNQX binds with equal affinity to two agonist states of quisqualate receptors.Biochemical pharmacology, 38(19), 3207-3212.
USBio References
No references available
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