(8R,9S,10R,13S,14S,16S,17R)-17-(2-Chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Clobetasol Propionate Impurity E is an impurity of Clobetasol, which is a topical corticosteroid. Glucocorticoid; anti-inflammatory.
Synonyms
(8R,9S,10R,13S,14S,16S,17R)-17-(2-Chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Molecular Formula
C25H33ClO4
Solubility
Chloroform (Slightly), DMSO (Slightly)
Appearance
White to off-white solid
Method for Determining Identity
Proton NMR Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Ethyl Acetate : Hexanes = 1 : 1; Visualized with UV, AMCS, and KMnO4; Single Spot, Rf = 0.60
Elemental Analysis
Calculated: %C: 69.35, %H: 7.68
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.