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453387 L-Noradrenaline ((−)-Norepinephrine) CAS: 51-41-2

Specifications
References
CAS Number
51-41-2
Grade
Highly Purified
MDL Number
MFCD00025592
Molecular Formula
C₈H₁₁NO₃
Molecular Weight
169.18
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; l-Arterenol; (-)- α-(Aminomethyl)-3,4-dihydroxy-benzyl Alcohol; 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol; (-)-Arterenol; (-)-Noradrenaline; (-)-Norepinephrine; (-)-α-(Aminomethyl)protocatechuyl Alcohol; (R)-(-)-Norepinephrine; (R)-Noradrenaline; (R)-Norepinephrine; Adrenor; Aktamin; Arterenol; Levarterenol; Levoarterenol; Levonor; Levonoradrenaline; Levonorepinephrine; Levophed; Nor-Epirenan; Noradrenalin; Noradrenaline; Norartrinal; Norepinephrine; Norepirenamine; Sympathin E; l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol; l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol; l-3,4-Dihydroxyphenylethanolamine; l-Arterenol; l-Noradrenaline; l-Norepinephrine; l-α-(Aminomethyl)-3,4-dihydroxybenzyl Alcohol

Norepinephrine is a hormone and neurotransmitter that is released by the adrenal medulla. It has vasoconstrictor and bronchodilator effects, as well as other actions such as increasing metabolic rate and blood pressure. Norepinephrine binds to β-adrenergic receptors on cells, causing them to release cyclic adenosine monophosphate (cAMP) in response. cAMP activates protein kinase A, which phosphorylates proteins leading to increased cell activity. The binding of norepinephrine to β-adrenergic receptors also leads to the activation of voltage-dependent calcium channels and increased calcium ion permeability. This increase in intracellular calcium ions leads to muscle contraction and relaxation of smooth muscle in the lungs, uterus, stomach, intestines and bladder. Norepinephrine can be used in a luminescence immunoassay for the measurement of noradrenaline levels in human serum or plasma samples.

Synonyms
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; l-Arterenol; (-)- α-(Aminomethyl)-3,4-dihydroxy-benzyl Alcohol; 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol; (-)-Arterenol; (-)-Noradrenaline; (-)-Norepinephrine; (-)-α-(Aminomethyl)protocatechuyl Alcohol; (R)-(-)-Norepinephrine; (R)-Noradrenaline; (R)-Norepinephrine; Adrenor; Aktamin; Arterenol; Levarterenol; Levoarterenol; Levonor; Levonoradrenaline; Levonorepinephrine; Levophed; Nor-Epirenan; Noradrenalin; Noradrenaline; Norartrinal; Norepinephrine; Norepirenamine; Sympathin E; l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol; l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol; l-3,4-Dihydroxyphenylethanolamine; l-Arterenol; l-Noradrenaline; l-Norepinephrine; l-α-(Aminomethyl)-3,4-dihydroxybenzyl Alcohol
CAS No
51-41-2
Molecular Formula
C₈H₁₁NO₃
Molecular Weight
169.18
Appearance
White to off-white solid
Purity
≥99%
Melting Point
>205°C (dec.)
Solubility
Aqueous Acid (Slightly), DMSO (Slightly)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Auchet, T., et al.: Ann. Intensive Care, 7, 1-9 (2017)|2. Littlejohn NK, et al. Cell Rep. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor.|3. MacGregor DA, et al. Chest. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes.
USBio References
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