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468873 XL888 CAS: 1149705-71-4

Specifications
CAS Number
1149705-71-4
Grade
Highly Purified
Molecular Formula
C29H37N5O3
Molecular Weight
503.64
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C

XL888, is a heat shock protein 90 (Hsp90) inhibitor. HSP90, is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.1 XL888 is an ATP-competitive inhibitor of Hsp90.2 Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.3,4,5 XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice

Molecular Formula
C29H37N5O3
Molecular Weight
503.64
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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