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A2297-39A Antibiotic UCN-02 (UCN 02) CAS: 121569-61-7

Specifications
References
CAS Number
121569-61-7
Grade
Highly Purified
Molecular Formula
C28H26N4O4
Molecular Weight
482.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
UCN 02

UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Purity: >95% by HPLC
Solubility: Soluble in ethyl acetate, ethanol, DMF or DMSO.
Related to: Staurosporine, Antibiotic UCN-01
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of |mitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase |pathway. Facchinetti M.M. et al. Cancer Res. 2004, 64, 3629. 2. UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti- cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 3. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.
USBio References
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