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A2298-78 Apigenin (4',5,7-Trihydroxyflavone) CAS: 520-36-5

Specifications
References
CAS Number
520-36-5
Grade
Highly Purified
MDL Number
MFCD00006831
Molecular Formula
C₁₅H₁₀O₅
Molecular Weight
270.24
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-Trihydroxyflavone; Pelargidenon 1449

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignan. Apigenin is a 270Da flavonoid, which belongs to the flavone group of glycosides. It is synthesized by a wide variety of plants including cereals, grains, tea and oranges. Apigenin has been used as a calibration standard for the quantification of Hieracium pannosum Boiss, Juniperus sp, using high-performance liquid chromatography (HPLC) with Diode-Array Detection (DAD). It has been used to study effect on hormone secretion in the human adrenocortical H295R cells.

Synonyms
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-Trihydroxyflavone; Pelargidenon 1449
CAS No
520-36-5
Molecular Formula
C₁₅H₁₀O₅
Molecular Weight
270.24
Appearance
Light yellow to dark yellow solid
Purity
≥97%
Melting Point
>300°C (lit.)
Solubility
DMSO (Slightly), Methanol (Slightly, Heated)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994); Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994); Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)
USBio References
No references available
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