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A3690 Ascochlorin (Antibiotic LL-Z 1272 gamma) CAS: 26166-39-2

Specifications
References
CAS Number
26166-39-2
Grade
Highly Purified
Molecular Formula
C23H29ClO4
Molecular Weight
404.9
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
Antibiotic LL-Z 1272 gamma

The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.

Purity: >95% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Source
Acremonium sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated |gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion |of renal carcinoma cells. Hong S. et al. J. Biol. Chem. 2005, 280, 25202. |2. Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al. |Biochem. Biophys. Res. Commun. 2005, 329, 46. |3. Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al. J. Med. Chem. 2003, |46, 4113.
USBio References
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