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C5836 Clavulanic Acid, Potassium Salt (MM 14151, Potassium Clavulanate) CAS: 61177-45-5

Specifications
References
CAS Number
61177-45-5
Grade
Highly Purified
MDL Number
MFCD01710901
Molecular Formula
C8H8KNO5
Molecular Weight
237.25
EU Commodity Code
38220090
UN DOT Shipping
UN3135 PGII Class 4.1
Shipping Temp
RT
Storage Temp
-20°C
Timentin; Ticarcillin; MM 14151; [2R-(2α,3Z,5α)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptane-2-carboxylate potassium salt

Clavulanic acid is a beta-lactam antibiotic produced by several species of the genus Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic but is a potent inhibitor of beta- lactamases. In combination with penicillin and cephalosporins it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the beta-lactamase.

Synonyms
Timentin; Ticarcillin; MM 14151; [2R-(2α,3Z,5α)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptane-2-carboxylate potassium salt
CAS No
61177-45-5
Molecular Formula
C8H8KNO5
Molecular Weight
237.25
Appearance
Brownish orange solid
Purity
≥95%
Melting Point
>170.5°C (dec)
Solubility
Water (Hot, Sparingly)
Atmosphere
Inert Gas
Method for Determining Identity
Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
C18; Acetonitrile: Water= 9:5; Visualized with UV and Ninhydrin; single spot, Rf= 0.55
Potassium
~16% by Ion chromatography
Elemental Analysis
Calculated: %C: 40.50, %H: 3.40, %N: 5.90
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under Inert atmosphere.
References
Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)
USBio References
No references available
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