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C7505-15 Cochlioquinone A (Luteoleersin) CAS: 32450-25-2

Specifications
References
CAS Number
32450-25-2
Grade
Highly Purified
Molecular Formula
C30H44O8
Molecular Weight
532.67
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
Luteoleersin

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has been recently shown to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

Purity: >99% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Related to: Cochlioquinone B
Source
Bipolaris leersia
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from |Bipolaris brizae and Stachybotrys chartarum. Yoganathan K. et al. J. Antibiot. 2004, 57, 59. |2. Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H.J. et al. Bioorg. Med. |Chem. 2003, 11, 4743. |3. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H.B. et al. J. |Antibiot. 2003, 56, 967. |4. Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. |Lim C.-H. et al. J. Pesticide Sci. 1996, 21, 213.
USBio References
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