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D1074-75 Darifenacin Hydrobromide ((3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3-pyrrolidineacetamide Hydrobromide;Enablex; Emselex) CAS: 133099-07-7

Specifications
References
CAS Number
133099-07-7
Grade
Highly Purified
MDL Number
MFCD08141803
Molecular Formula
C₂₈H₃₁BrN₂O₂
Molecular Weight
507.46
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetamide Hydrobromide; Enablex; Emselex

Used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

Synonyms
(3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetamide Hydrobromide; Enablex; Emselex
CAS No
133099-07-7 Free amine: 133099-04-4
Molecular Formula
C₂₈H₃₁BrN₂O₂
Molecular Weight
507.46
Appearance
White to off-white solid
Purity
≥98%
Melting Point
230ºC
Residue on Ignition
≤0.1%
Loss on Drying
≤1.0%
Specific Optical Rotation
+44 to +49º
Related Impurities
Single Impurity:≤0.2% Total Impurity:≤0.5%
Residual Solvents
Dichloromethane:≤0.06% 1-Butanol:≤0.5% Toluene:≤0.089%
Heavy Metals
≤0.002%
Solubility
Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
Storage
-20°C
References
Beaumont, K.C., et al.: Xenobiotica, 28, 63 (1998), Chapple, C.R., et al.: Expert Opin. Invest. Drugs, 13, 1493 (2004), Haab, F., et al.: Eur. Urol., 45, 420 (2004)
USBio References
No references available
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