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D1773 O-Deacetyl-ravidomycin (Antibiotic AY 26623) CAS: 88580-27-2

Specifications
References
CAS Number
88580-27-2
Grade
Highly Purified
Molecular Formula
C29H31NO8
Molecular Weight
521.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
Antibiotic AY 26623

O-deacetyl-ravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light dependent antitumour activity. Microbial Screening Technologies in-house bioassays detected weak antibacterial and antifungal activity. O-Deacetyl-ravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor.

Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, Gilvocarcin V
Source
Streptomyces sp. MST-AS5883
Purity
~95% by HPLC
Form
Supplied as a yellow solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al. J. Antibiot. 1998, 51, 1105. 2. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985. 3. Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al. Antimicrob. Agents Chemother. 1986, 29, 861. 4. Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. Rakhit S. et al. Antimicrob. Agents Chemother. 1986, 29, 861.
USBio References
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