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H9036-25 o-Hydroxy Atorvastatin, Dihydrate Monosodium Salt CAS: 1421760-64-4

Specifications
References
CAS Number
1421760-64-4
Grade
Highly Purified
Molecular Formula
C33H38FN2NaO8
Molecular Weight
632.65
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Dihydrate Monosodium Salt;|BMS 243887-01; PD 152873; o-Hydroxyatorvastatin Dihydrate Monosodium Salt

A metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

CAS No
1421760-64-4
Molecular Formula
C33H38FN2NaO8
Solubility
Methanol (Slightly)
Melting Point
>140°C (dec)
Method for Determining Identity
Proton NMR (CD3OD), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2: Dichloromethane: Methanol: Acetic Acid= 9: 1: 0.1; Visualized with UV and KMnO4; Single spot; Rf=0.50.
Water Content (KF)
~7%
Sodium Content (Ion Chromatography)
~4%
Elemental Analysis
Calculated: C= 62.65%, H= 6.05%, N= 4.43%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Source
Synthetic
Purity
≥90%
Form
Supplied as an off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007)
USBio References
No references available
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