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M3022-05 L-Methionine [R,S]-Sulfoximine CAS: 15985-39-4

Specifications
References
CAS Number
15985-39-4
Grade
Highly Purified
Molecular Formula
C₅H₁₂N₂O₃S
Molecular Weight
180.23
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid

Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0mM (52% inhibition occured at 100mM).

Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.
Synonyms
L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid
CAS Number
15985-39-4
Molecular Formula
C₅H₁₂N₂O₃S
Molecular Weight
180.23
Appearance
White to off-white solid
Purity
≥98%
Melting Point
>210°C (dec.)
Solubility
Formic Acid, Water
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)
USBio References
No references available
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