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V2049 Vancomycin Hydrochloride CAS: 1404-93-9

Specifications
References
CAS Number
1404-93-9
Grade
Reagent Grade
MDL Number
MFCD03613611
Molecular Formula
C66H75Cl2N9O24×HCl
Molecular Weight
1485.7
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Lyphocin; Meek; Vancocin Hydrochloride; Vancocine Hydrochloride; Vancocyn; Vancor

Vancomycin is an aminoglycoside antibiotic, used in the treatment of infections caused by Gram-positive bacteria. vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). The main target of this antibiotic is the D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors, used by bacteria for constructing their cell walls. This prevents the reaction used to link peptidoglycan precursors together from taking place. Vancomycin binds with the substrate, not the enzyme, in contrast to the way penicillin inhibits peptidoglycan synthesis.

The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Under normal circumstances, this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis in two ways. It prevents the synthesis of the long polymers of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) that form the backbone strands of the bacterial cell wall, and it prevents the backbone polymers that do manage to form from cross-linking with each other.
Synonyms
Lyphocin; Meek; Vancocin Hydrochloride; Vancocine Hydrochloride; Vancocyn; Vancor
CAS No
1404-93-9
Molecular Formula
C66H75Cl2N9O24×HCl
Molecular Weight
1485.7
Potency (as Vancomycin)
≥900ug/mg
Appearance
White to tan powder
pH (50mg/ml, 25°C)
2.5-4.5
Water (KF)
≤5%
Solubility (200mg/4ml dH2O)
Freely soluble in water, insoluble in ether and chloroform
Storage and Stability
Store at 4ºC. Stable for 12 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Salyers, A., Nature 384: 304 (1996). 2. Brickner, S.J., Chemistry and Industry, 131-125, Feb. 1997. 3. Dutka-Malen, S., et al., Molecular and General Genetics 224: 364-372 (1990). 4. Nicas, T.I., et al., (1996) Antimicrobial Agents and Chemotherapy, 40: 2,194-2,199. 5. Schafer, M., et al., (1996) Structure 4: 1,509-1,515. 6. McKintyre, J., Bull, A.T. and Bunch, A.W. (1996) Biotechnology and Bioengineering 49: 412-420. 7. McIntyre, J., Bunch, A.W. and Bull, A.T. (1997) Vancomycin production by Amycolaptosis orientalis growing in chemostat culture with cell recycle.
USBio References
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