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V2121-47 Venturicidin A (Aabomycin A1) CAS: 33538-71-5

Specifications
References
CAS Number
33538-71-5
Grade
Highly Purified
Molecular Formula
C41H67NO11
Molecular Weight
749.97
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
Aabomycin A1

The macrolide antibiotic Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Originally isolated as an antifungal agent.

Storage and Stability
Lyophilized powder may be stored at 4°C. Stable for 12 months at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
Streptomyces sp. MST-117594
Purity
~95% by HPLC
Form
Supplied as a lyophilized powder. Soluble in ethanol, methanol, DMF or DMSO.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Miedema H. et al., Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. (1994) Biochem. Biophys. Res. Commun. 203:1005. 2. Matsuno-Yagi A. & Hatefi Y. J, .Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. (1993) Biol. Chem. 268:6168. 3. Galanis M. et al., Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. (1989) FEBS Lett. 249:333.
USBio References
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