Staphylomycin S, PA 114B2, Antibiotic 899, Antibiotic PA 114B2, Antibiotic 1745Z3B, Factor S
Virginiamycin S1 is a main component of virginiamycin preparations.
Virginiamycin S1 is one of a family of depsipeptide antibiotic co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin S1 also known as Staphylomycin S and Factor S, among other synonyms were discovered independently and named by several groups leading to considerable confusion in the literature. Virginiamycin S1 acts a synergist binding to the conformational change induced by ostreogrycin A of the peptidyl transferase centre of the 50S ribosome. Virginiamycin S1 differs from virginiamycin B in lacking the dimethylamino moiety on the phenyl ring.
Synonyms
Staphylomycin S, PA 114B2, Antibiotic 899, Antibiotic PA 114B2, Antibiotic 1745Z3B, Factor S
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
References
1. The structures of the minor components of virginiamycin S. Vanderhaeghe, H. et al., Tet. Lett. 1971, 2687 2. Virginiamycin: nomenclature. Crooy P. and De Neys R. J. Antibiot. 1972, 25, 371. 3. A new species of Streptomyces producing virginiamycin family antibiotics. Ogata, K. et al., J. Antibiot. 1978, 31, 1313.