Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups leading to considerable confusion in the literature. Viriginiamycin B acts as a synergist binding to the conformational change in the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
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