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V2123-50 Vioxx (Rofecoxib, MK-0966, 4-[4-(methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone) CAS: 162011-90-7

Specifications
References
CAS Number
162011-90-7
Grade
Highly Purified
Molecular Formula
C17H14O4S
Molecular Weight
314.36
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Rofecoxib, MK-0966, 4-[4-(methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone

A selective cyclooxygenase-2 (COX-2) inhibitor. Use as an anti-inflammatory.

Melting Point
206-208ºC
Solubility
Chloroform, DMSO
Purity
~90%
Method for Determining Identity
Proton Spectroscopic Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: 9: 1; Visualized with UV and AMCS; Single spot; Rf=0.65.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Liu B, et al. Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries. Sci Rep. 2017 Aug 21;7(1):8927. doi: 10.1038/s41598-017-09288-w.
USBio References
1. Liu B, et al. Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries. Sci Rep. 2017 Aug 21;7(1):8927. doi: 10.1038/s41598-017-09288-w.
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